The First Things First 2000 manifesto, written and launched by Adbusters magazine, was an updated version of the earlier First Things First manifesto written and published in 1964 by British designer Ken Garland.

The 2000 manifesto was signed by a group of 33 figures from the international graphic design community, and simultaneously published in Adbusters (Canada), Emigre (Issue 51) and AIGA Journal of Graphic Design (United States), Eye Magazine (No.33) and Blueprint (Britain) and Items (Netherlands).

Its aim was to generate discussion about the graphic design profession's priorities in the design press and at design schools. Some designers welcomed this attempt to reopen the debate, while others rejected the manifesto.